About Receptor-interacting serine/threonine-protein kinase 1
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a protein
from Homo sapiens identified by UniProt accession
Q13546, 671 residues long.
MolForge cross-references it against 0 known binders and
446 disease associations.
Target properties
| Protein name | Receptor-interacting serine/threonine-protein kinase 1 |
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| UniProt accession | Q13546 |
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| Gene | RIPK1 |
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| Organism | Homo sapiens |
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| Length | 671 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (446)
Diseases linked to this target (Open Targets).
- immunodeficiency disease · score 0.65
- autoinflammation with episodic fever and lymphadenopathy · score 0.65
- neurodegenerative disease · score 0.52
- severe acute respiratory syndrome · score 0.50
- inborn error of immunity · score 0.49
- immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome · score 0.49
- multiple sclerosis · score 0.42
- Parkinson disease · score 0.42
- lysosomal storage disease · score 0.42
- Alzheimer disease · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13546-F1 | alphafold | PREDICTED | 69.74 | — |
Amino-acid sequence (671 residues)
MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR QNVAYNREEE RRRRVSHDPF AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD PGTAGPRVWY RPIPSHMPSL HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ IGAYNYMEIG GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA QALHQCSRID LLSSLIYVSQ N
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