Histone deacetylase 1 (HDAC1)

About Histone deacetylase 1

Histone deacetylase 1 (HDAC1) is a protein from Homo sapiens identified by UniProt accession Q13547, 482 residues long. MolForge cross-references it against 0 known binders and 605 disease associations.

Target properties

Protein name	Histone deacetylase 1
UniProt accession	Q13547
Gene	HDAC1
Organism	Homo sapiens
Length	482 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (15)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (605)

Diseases linked to this target (Open Targets).

neoplasm · score 0.57
multiple myeloma · score 0.57
unspecified peripheral T-cell lymphoma · score 0.52
Cutaneous T-cell lymphoma · score 0.52
T-cell non-Hodgkin lymphoma · score 0.51
cancer · score 0.50
graft versus host disease · score 0.39
primary myelofibrosis · score 0.38
lymphoma · score 0.37
Rett syndrome · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13547-F1	alphafold	PREDICTED	86.22	—

Amino-acid sequence (482 residues)

MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards