Dynactin subunit 2 (DCTN2)

About Dynactin subunit 2

Dynactin subunit 2 (DCTN2) is a protein from Homo sapiens identified by UniProt accession Q13561, 401 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Dynactin subunit 2
UniProt accession	Q13561
Gene	DCTN2
Organism	Homo sapiens
Length	401 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.24
ovarian cancer · score 0.23
Charcot-Marie-Tooth disease · score 0.11
cancer · score 0.08
neoplasm · score 0.08
hepatocellular carcinoma · score 0.07
DNA methylation · score 0.03
type 2 diabetes mellitus · score 0.03
type 1 diabetes mellitus · score 0.03
basophil count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13561-F1	alphafold	PREDICTED	76.57	—

Amino-acid sequence (401 residues)

MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGEYEMLG EGLGVKETPQ QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVLLAK QLAALKQQLV ASHLEKLLGP DAAINLTDPD GALAKRLLLQ LEATKNSKGG SGGKTTGTPP DSSLVTYELH SRPEQDKFSQ AAKVAELEKR LTELETAVRC DQDAQNPLSA GLQGACLMET VELLQAKVSA LDLAVLDQVE ARLQSVLGKV NEIAKHKASV EDADTQSKVH QLYETIQRWS PIASTLPELV QRLVTIKQLH EQAMQFGQLL THLDTTQQMI ANSLKDNTTL LTQVQTTMRE NLATVEGNFA SIDERMKKLG K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards