Neurogenic differentiation factor 1 (NEUROD1)

About Neurogenic differentiation factor 1

Neurogenic differentiation factor 1 (NEUROD1) is a protein from Homo sapiens identified by UniProt accession Q13562, 356 residues long. MolForge cross-references it against 0 known binders and 335 disease associations.

Target properties

Protein name	Neurogenic differentiation factor 1
UniProt accession	Q13562
Gene	NEUROD1
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (335)

Diseases linked to this target (Open Targets).

maturity-onset diabetes of the young type 6 · score 0.71
type 2 diabetes mellitus · score 0.65
maturity-onset diabetes of the young · score 0.55
MODY · score 0.53
neurodegenerative disease · score 0.53
permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome · score 0.38
retinitis pigmentosa · score 0.37
retinopathy · score 0.37
Retinal dystrophy · score 0.36
body mass index · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13562-F1	alphafold	PREDICTED	62.11	—

Amino-acid sequence (356 residues)

MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DDLETMNAEE DSLRNGGEEE DEDEDLEEEE EEEEEDDDQK PKRRGPKKKK MTKARLERFK LRRMKANARE RNRMHGLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KSPDLVSFVQ TLCKGLSQPT TNLVAGCLQL NPRTFLPEQN QDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT MHYPAATLAG AQSHGSIFSG TAAPRCEIPI DNIMSFDSHS HHERVMSAQL NAIFHD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards