About NEDD8-activating enzyme E1 regulatory subunit
NEDD8-activating enzyme E1 regulatory subunit (NAE1) is a protein
from Homo sapiens identified by UniProt accession
Q13564, 534 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | NEDD8-activating enzyme E1 regulatory subunit |
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| UniProt accession | Q13564 |
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| Gene | NAE1 |
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| Organism | Homo sapiens |
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| Length | 534 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with dysmorphic facies and ischiopubic hypoplasia · score 0.65
- neurodegenerative disease · score 0.53
- acute myeloid leukemia · score 0.30
- diastolic blood pressure · score 0.14
- myelodysplastic syndrome · score 0.10
- non-small cell lung carcinoma · score 0.10
- C-reactive protein measurement · score 0.09
- hepatocellular carcinoma · score 0.09
- diet measurement · score 0.09
- intrahepatic cholangiocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13564-F1 | alphafold | PREDICTED | 96.23 | — |
Amino-acid sequence (534 residues)
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
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