Interferon regulatory factor 5 (IRF5)

About Interferon regulatory factor 5

Interferon regulatory factor 5 (IRF5) is a protein from Homo sapiens identified by UniProt accession Q13568, 498 residues long. MolForge cross-references it against 0 known binders and 340 disease associations.

Target properties

Protein name	Interferon regulatory factor 5
UniProt accession	Q13568
Gene	IRF5
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (340)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.50
systemic lupus erythematosus · score 0.46
inflammatory bowel disease · score 0.44
eosinophil count · score 0.40
Sjogren syndrome · score 0.40
lymphocyte count · score 0.36
ulcerative colitis · score 0.36
systemic scleroderma · score 0.35
autoimmune disease · score 0.34
platelet count · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13568-F1	alphafold	PREDICTED	72.62	—

Amino-acid sequence (498 residues)

MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards