G/T mismatch-specific thymine DNA glycosylase (TDG)

About G/T mismatch-specific thymine DNA glycosylase

G/T mismatch-specific thymine DNA glycosylase (TDG) is a protein from Homo sapiens identified by UniProt accession Q13569, 410 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	G/T mismatch-specific thymine DNA glycosylase
UniProt accession	Q13569
Gene	TDG
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

low grade glioma · score 0.25
ovarian cancer · score 0.23
body height · score 0.23
glioblastoma multiforme · score 0.20
esophageal cancer · score 0.14
cor pulmonale · score 0.13
BMI-adjusted waist circumference · score 0.12
central corneal thickness · score 0.12
hereditary breast ovarian cancer syndrome · score 0.12
Hereditary breast and ovarian cancer syndrome · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13569-F1	alphafold	PREDICTED	70.20	—

Amino-acid sequence (410 residues)

MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA QEPVQEAPKG RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD TFKVKRKVDR FNGVSEAELL TKTLPDILTF NLDIVIIGIN PGLMAAYKGH HYPGPGNHFW KCLFMSGLSE VQLNHMDDHT LPGKYGIGFT NMVERTTPGS KDLSSKEFRE GGRILVQKLQ KYQPRIAVFN GKCIYEIFSK EVFGVKVKNL EFGLQPHKIP DTETLCYVMP SSSARCAQFP RAQDKVHYYI KLKDLRDQLK GIERNMDVQE VQYTFDLQLA QEDAKKMAVK EEKYDPGYEA AYGGAYGENP CSSEPCGFSS NGLIESVELR GESAFSGIPN GQWMTQSFTD QIPSFSNHCG TQEQEEESHA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards