About Melatonin-related receptor
Melatonin-related receptor (GPR50) is a protein
from Homo sapiens identified by UniProt accession
Q13585, 617 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Melatonin-related receptor |
|---|
| UniProt accession | Q13585 |
|---|
| Gene | GPR50 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 617 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- hepatocellular carcinoma · score 0.09
- cancer · score 0.07
- breast cancer · score 0.06
- neoplasm · score 0.04
- idiopathic scoliosis · score 0.01
- type 2 diabetes mellitus · score 0.01
- bipolar disorder · score 0.01
- non-small cell lung carcinoma · score 0.01
- mood disorder · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13585-F1 | alphafold | PREDICTED | 66.23 | — |
Amino-acid sequence (617 residues)
MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY HDVVVIDVED DPDEMAV
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