About GRB2-related adapter protein
GRB2-related adapter protein (GRAP) is a protein
from Homo sapiens identified by UniProt accession
Q13588, 217 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | GRB2-related adapter protein |
|---|
| UniProt accession | Q13588 |
|---|
| Gene | GRAP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.44
- 1,5 anhydroglucitol measurement · score 0.05
- lymphocyte count · score 0.05
- severe combined immunodeficiency due to CARD11 deficiency · score 0.05
- reticular dysgenesis · score 0.04
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.04
- immunodeficiency 18 · score 0.04
- Wiskott-Aldrich syndrome · score 0.04
- Chronic mucocutaneous candidosis · score 0.04
- schizophrenia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13588-F1 | alphafold | PREDICTED | 85.87 | — |
Amino-acid sequence (217 residues)
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKKRQIFLRD EEPLLKSPGA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER PDPHWWRGRS CGRVGFFPRS YVQPVHL
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