Transformer-2 protein homolog alpha (TRA2A)

About Transformer-2 protein homolog alpha

Transformer-2 protein homolog alpha (TRA2A) is a protein from Homo sapiens identified by UniProt accession Q13595, 282 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Transformer-2 protein homolog alpha
UniProt accession	Q13595
Gene	TRA2A
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
forced expiratory volume · score 0.27
schizophrenia · score 0.25
myeloid white cell count · score 0.21
vital capacity · score 0.20
age at menopause · score 0.19
chronotype measurement · score 0.07
appendicular lean mass · score 0.07
eosinophil peroxidase deficiency · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13595-F1	alphafold	PREDICTED	58.86	—

Amino-acid sequence (282 residues)

MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS RSRSKSRSRS RRHSHRRYTR SRSHSHSHRR RSRSRSYTPE YRRRRSRSHS PMSNRRRHTG SRANPDPNTC LGVFGLSLYT TERDLREVFS RYGPLSGVNV VYDQRTGRSR GFAFVYFERI DDSKEAMERA NGMELDGRRI RVDYSITKRA HTPTPGIYMG RPTHSGGGGG GGGGGGGGGG GRRRDSYYDR GYDRGYDRYE DYDYRYRRRS PSPYYSRYRS RSRSRSYSPR RY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards