KRR1 small subunit processome component homolog (KRR1)

About KRR1 small subunit processome component homolog

KRR1 small subunit processome component homolog (KRR1) is a protein from Homo sapiens identified by UniProt accession Q13601, 381 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	KRR1 small subunit processome component homolog
UniProt accession	Q13601
Gene	KRR1
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
polycystic ovary syndrome · score 0.22
age at menopause · score 0.19
cup-to-disc ratio measurement · score 0.15
intrathoracic organ injury · score 0.13
metabolite measurement · score 0.11
bone density · score 0.08
urate measurement · score 0.08
goiter · score 0.05
Spontaneous pneumothorax · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13601-F1	alphafold	PREDICTED	81.13	—

Amino-acid sequence (381 residues)

MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN PRGLLEESSF ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT VCTTKKTFDP YIIIRARDLI KLLARSVSFE QAVRILQDDV ACDIIKIGSL VRNKERFVKR RQRLIGPKGS TLKALELLTN CYIMVQGNTV SAIGPFSGLK EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE RFLPQFKHKN VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV KKAKNKKLGA LTAEEIALKM EADEKKKKKK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards