Deoxyribonuclease gamma (DNASE1L3)

About Deoxyribonuclease gamma

Deoxyribonuclease gamma (DNASE1L3) is a protein from Homo sapiens identified by UniProt accession Q13609, 305 residues long. MolForge cross-references it against 0 known binders and 179 disease associations.

Target properties

Protein name	Deoxyribonuclease gamma
UniProt accession	Q13609
Gene	DNASE1L3
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (179)

Diseases linked to this target (Open Targets).

autosomal systemic lupus erythematosus type 16 · score 0.68
systemic lupus erythematosus · score 0.53
Autosomal recessive systemic lupus erythematosus · score 0.46
blood protein measurement · score 0.37
systemic scleroderma · score 0.36
BMI-adjusted waist-hip ratio · score 0.34
limited scleroderma · score 0.28
BMI-adjusted waist circumference · score 0.27
waist-hip ratio · score 0.26
genetic disorder · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13609-F1	alphafold	PREDICTED	91.84	—

Amino-acid sequence (305 residues)

MSRELAPLLL LLLSIHSALA MRICSFNVRS FGESKQEDKN AMDVIVKVIK RCDIILVMEI KDSNNRICPI LMEKLNRNSR RGITYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKRSYHYH DYQDGDADVF SREPFVVWFQ SPHTAVKDFV IIPLHTTPET SVKEIDELVE VYTDVKHRWK AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PRFVWLIGDQ EDTTVKKSTN CAYDRIVLRG QEIVSSVVPK SNSVFDFQKA YKLTEEEALD VSDHFPVEFK LQSSRAFTNS KKSVTLRKKT KSKRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards