Periodic tryptophan protein 1 homolog (PWP1)

About Periodic tryptophan protein 1 homolog

Periodic tryptophan protein 1 homolog (PWP1) is a protein from Homo sapiens identified by UniProt accession Q13610, 501 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Periodic tryptophan protein 1 homolog
UniProt accession	Q13610
Gene	PWP1
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
monocyte percentage of leukocytes · score 0.18
balding measurement · score 0.14
fat body mass · score 0.12
body fat percentage · score 0.11
Immature Reticulocyte Fraction Measurement · score 0.09
body weight · score 0.08
hepatocellular carcinoma · score 0.07
non-small cell lung carcinoma · score 0.07
body height · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13610-F1	alphafold	PREDICTED	80.91	—

Amino-acid sequence (501 residues)

MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS DEEETGSPSE DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY DEEGDPDAET LGESLLGLTV YGSNDQDPYV TLKDTEQYER EDFLIKPSDN LIVCGRAEQD QCNLEVHVYN QEEDSFYVHH DILLSAYPLS VEWLNFDPSP DDSTGNYIAV GNMTPVIEVW DLDIVDSLEP VFTLGSKLSK KKKKKGKKSS SAEGHTDAVL DLSWNKLIRN VLASASADNT VILWDMSLGK PAASLAVHTD KVQTLQFHPF EAQTLISGSY DKSVALYDCR SPDESHRMWR FSGQIERVTW NHFSPCHFLA STDDGFVYNL DARSDKPIFT LNAHNDEISG LDLSSQIKGC LVTASADKYV KIWDILGDRP SLVHSRDMKM GVLFCSSCCP DLPFIYAFGG QKEGLRVWDI STVSSVNEAF GRRERLVLGS ARNSSISGPF GSRSSDTPME S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards