About Phosphatidylinositol-3-phosphate phosphatase MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1 (MTMR1) is a protein
from Homo sapiens identified by UniProt accession
Q13613, 665 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3-phosphate phosphatase MTMR1 |
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| UniProt accession | Q13613 |
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| Gene | MTMR1 |
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| Organism | Homo sapiens |
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| Length | 665 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.25
- Blackfan-Diamond anemia · score 0.08
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- thrombocytopenia 4 · score 0.06
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.06
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- hemolytic anemia due to adenylate kinase deficiency · score 0.05
- Constitutional sideroblastic anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13613-F1 | alphafold | PREDICTED | 84.48 | — |
Amino-acid sequence (665 residues)
MDRPAAAAAA GCEGGGGPNP GPAGGRRPPR AAGGATAGSR QPSVETLDSP TGSHVEWCKQ LIAATISSQI SGSVTSENVS RDYKALRDGN KLAQMEEAPL FPGESIKAIV KDVMYICPFM GAVSGTLTVT DFKLYFKNVE RDPHFILDVP LGVISRVEKI GAQSHGDNSC GIEIVCKDMR NLRLAYKQEE QSKLGIFENL NKHAFPLSNG QALFAFSYKE KFPINGWKVY DPVSEYKRQG LPNESWKISK INSNYEFCDT YPAIIVVPTS VKDDDLSKVA AFRAKGRVPV LSWIHPESQA TITRCSQPLV GPNDKRCKED EKYLQTIMDA NAQSHKLIIF DARQNSVADT NKTKGGGYES ESAYPNAELV FLEIHNIHVM RESLRKLKEI VYPSIDEARW LSNVDGTHWL EYIRMLLAGA VRIADKIESG KTSVVVHCSD GWDRTAQLTS LAMLMLDSYY RTIKGFETLV EKEWISFGHR FALRVGHGND NHADADRSPI FLQFVDCVWQ MTRQFPSAFE FNELFLITIL DHLYSCLFGT FLCNCEQQRF KEDVYTKTIS LWSYINSQLD EFSNPFFVNY ENHVLYPVAS LSHLELWVNY YVRWNPRMRP QMPIHQNLKE LLAVRAELQK RVEGLQREVA TRAVSSSSER GSSPSHSATS VHTSV
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