About Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (MTMR2) is a protein
from Homo sapiens identified by UniProt accession
Q13614, 643 residues long.
MolForge cross-references it against 0 known binders and
278 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 |
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| UniProt accession | Q13614 |
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| Gene | MTMR2 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (278)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 4B1 · score 0.76
- Charcot-Marie-Tooth disease type 4 · score 0.55
- genetic disorder · score 0.50
- platelet component distribution width · score 0.37
- demyelinating hereditary motor and sensory neuropathy · score 0.37
- mean corpuscular volume · score 0.36
- self reported educational attainment · score 0.34
- cortical thickness · score 0.28
- diffuse plaque measurement · score 0.27
- breast adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13614-F1 | alphafold | PREDICTED | 88.47 | — |
Amino-acid sequence (643 residues)
MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSADNFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD PPFVLDASLG VINRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL PLFAFEYKEV FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADKVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKRTVSL WSYINSQLED FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHNRYKEL LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV
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