About Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is a protein
from Homo sapiens identified by UniProt accession
Q13627, 763 residues long.
MolForge cross-references it against 0 known binders and
259 disease associations.
Target properties
| Protein name | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
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| UniProt accession | Q13627 |
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| Gene | DYRK1A |
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| Organism | Homo sapiens |
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| Length | 763 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (259)
Diseases linked to this target (Open Targets).
- DYRK1A-related intellectual disability syndrome · score 0.73
- complex neurodevelopmental disorder · score 0.62
- Microcephaly · score 0.61
- Intellectual disability · score 0.55
- genetic disorder · score 0.55
- Rare genetic intellectual disability with developmental anomaly · score 0.53
- absent or delayed speech development · score 0.51
- Deeply set eye · score 0.51
- Feeding difficulties · score 0.51
- Seizure · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13627-F1 | alphafold | PREDICTED | 66.44 | — |
Amino-acid sequence (763 residues)
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS
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