GDP-L-fucose synthase (GFUS)

About GDP-L-fucose synthase

GDP-L-fucose synthase (GFUS) is a protein from Homo sapiens identified by UniProt accession Q13630, 321 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	GDP-L-fucose synthase
UniProt accession	Q13630
Gene	GFUS
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.22
serum metabolite measurement · score 0.21
mean corpuscular volume · score 0.12
Red cell distribution width · score 0.09
esophageal squamous cell carcinoma · score 0.09
neoplasm · score 0.06
protein measurement · score 0.06
HMG CoA reductase inhibitor use measurement · score 0.04
eosinophilic gastroenteritis · score 0.04
NK-cell enteropathy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13630-F1	alphafold	PREDICTED	95.80	—

Amino-acid sequence (321 residues)

MGEPQGSMRI LVTGGSGLVG KAIQKVVADG AGLPGEDWVF VSSKDADLTD TAQTRALFEK VQPTHVIHLA AMVGGLFRNI KYNLDFWRKN VHMNDNVLHS AFEVGARKVV SCLSTCIFPD KTTYPIDETM IHNGPPHNSN FGYSYAKRMI DVQNRAYFQQ YGCTFTAVIP TNVFGPHDNF NIEDGHVLPG LIHKVHLAKS SGSALTVWGT GNPRRQFIYS LDLAQLFIWV LREYNEVEPI ILSVGEEDEV SIKEAAEAVV EAMDFHGEVT FDTTKSDGQF KKTASNSKLR TYLPDFRFTP FKQAVKETCA WFTDNYEQAR K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards