About Cadherin-18
Cadherin-18 (CDH18) is a protein
from Homo sapiens identified by UniProt accession
Q13634, 790 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Cadherin-18 |
|---|
| UniProt accession | Q13634 |
|---|
| Gene | CDH18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 790 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.37
- mathematical ability · score 0.35
- leprosy · score 0.29
- PHF-tau measurement · score 0.27
- alcohol consumption measurement · score 0.26
- DNA methylation · score 0.26
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.25
- endometrial cancer · score 0.25
- ovarian neoplasm · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13634-F1 | alphafold | PREDICTED | 77.59 | — |
Amino-acid sequence (790 residues)
MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK DNEDNTASIL TRRRRFSRTV QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC HAEAFLSSAG LSTGALIAIL LCVLILLAIV VLFITLRRSK KEPLIISEED VRENVVTYDD EGGGEEDTEA FDITALRNPS AAEELKYRRD IRPEVKLTPR HQTSSTLESI DVQEFIKQRL AEADLDPSVP PYDSLQTYAY EGQRSEAGSI SSLDSATTQS DQDYHYLGDW GPEFKKLAEL YGEIESERTT
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