Trophoblast glycoprotein (TPBG)

About Trophoblast glycoprotein

Trophoblast glycoprotein (TPBG) is a protein from Homo sapiens identified by UniProt accession Q13641, 420 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Trophoblast glycoprotein
UniProt accession	Q13641
Gene	TPBG
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

body mass index · score 0.27
lean body mass · score 0.25
fat body mass · score 0.22
body weight · score 0.19
base metabolic rate measurement · score 0.15
whole body water mass · score 0.15
waist circumference · score 0.14
non-small cell lung carcinoma · score 0.09
renal cell carcinoma · score 0.08
neurofibrillary tangles measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13641-F1	alphafold	PREDICTED	82.16	—

Amino-acid sequence (420 residues)

MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards