Four and a half LIM domains protein 1 (FHL1)

About Four and a half LIM domains protein 1

Four and a half LIM domains protein 1 (FHL1) is a protein from Homo sapiens identified by UniProt accession Q13642, 323 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.

Target properties

Protein name	Four and a half LIM domains protein 1
UniProt accession	Q13642
Gene	FHL1
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (198)

Diseases linked to this target (Open Targets).

X-linked myopathy with postural muscle atrophy · score 0.80
myopathy · score 0.69
reducing body myopathy · score 0.62
Uruguay Faciocardiomusculoskeletal syndrome · score 0.56
Emery-Dreifuss muscular dystrophy · score 0.55
Abnormality of the cardiovascular system · score 0.51
X-linked Emery-Dreifuss muscular dystrophy · score 0.46
Myocardial Ischemia · score 0.39
Abnormality of the musculature · score 0.33
Crohn's disease · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13642-F1	alphafold	PREDICTED	72.61	—

Amino-acid sequence (323 residues)

MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG KRTVSRVSHP VSKARKPPVC HGKRLPLTLF PSANLRGRHP GGERTCPSWV VVLYRKNRSL AAPRGPGLVK APVWWPMKDN PGTTTASTAK NAP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards