Four and a half LIM domains protein 3 (FHL3)

About Four and a half LIM domains protein 3

Four and a half LIM domains protein 3 (FHL3) is a protein from Homo sapiens identified by UniProt accession Q13643, 280 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Four and a half LIM domains protein 3
UniProt accession	Q13643
Gene	FHL3
Organism	Homo sapiens
Length	280 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
body height · score 0.26
erythrocyte count · score 0.24
pulse pressure measurement · score 0.22
balding measurement · score 0.20
heel bone mineral density · score 0.20
bone quantitative ultrasound measurement · score 0.19
coronary artery disease · score 0.19
appendicular lean mass · score 0.17
rheumatoid arthritis · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13643-F1	alphafold	PREDICTED	91.39	—

Amino-acid sequence (280 residues)

MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards