About Ras and Rab interactor 1
Ras and Rab interactor 1 (RIN1) is a protein
from Homo sapiens identified by UniProt accession
Q13671, 783 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Ras and Rab interactor 1 |
|---|
| UniProt accession | Q13671 |
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| Gene | RIN1 |
|---|
| Organism | Homo sapiens |
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| Length | 783 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.19
- urate measurement · score 0.16
- mathematical ability · score 0.15
- ovarian carcinoma · score 0.13
- breast carcinoma · score 0.13
- prostate carcinoma · score 0.13
- BMI-adjusted waist-hip ratio · score 0.10
- hepatocellular carcinoma · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
- C-reactive protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13671-F1 | alphafold | PREDICTED | 66.88 | — |
Amino-acid sequence (783 residues)
MESPGESGAG SPGAPSPSSF TTGHLAREKP AQDPLYDVPN ASGGQAGGPQ RPGRVVSLRE RLLLTRPVWL QLQANAAAAL HMLRTEPPGT FLVRKSNTRQ CQALCMRLPE ASGPSFVSSH YILESPGGVS LEGSELMFPD LVQLICAYCH TRDILLLPLQ LPRAIHHAAT HKELEAISHL GIEFWSSSLN IKAQRGPAGG PVLPQLKARS PQELDQGTGA ALCFFNPLFP GDLGPTKREK FKRSFKVRVS TETSSPLSPP AVPPPPVPVL PGAVPSQTER LPPCQLLRRE SSVGYRVPAG SGPSLPPMPS LQEVDCGSPS SSEEEGVPGS RGSPATSPHL GRRRPLLRSM SAAFCSLLAP ERQVGRAAAA LMQDRHTAAG QLVQDLLTQV RAGPEPQELQ GIRQALSRAR AMLSAELGPE KLLSPKRLEH VLEKSLHCSV LKPLRPILAA RLRRRLAADG SLGRLAEGLR LARAQGPGAF GSHLSLPSPV ELEQVRQKLL QLLRTYSPSA QVKRLLQACK LLYMALRTQE GEGAGADEFL PLLSLVLAHC DLPELLLEAE YMSELLEPSL LTGEGGYYLT SLSASLALLS GLGQAHTLPL SPVQELRRSL SLWEQRRLPA THCFQHLLRV AYQDPSSGCT SKTLAVPPEA SIATLNQLCA TKFRVTQPNT FGLFLYKEQG YHRLPPGALA HRLPTTGYLV YRRAEWPETQ GAVTEEEGSG QSEARSRGEE QGCQGDGDAG VKASPRDIRE QSETTAEGGQ GQAQEGPAQP GEPEAEGSRA AEE
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