About 43 kDa receptor-associated protein of the synapse
43 kDa receptor-associated protein of the synapse (RAPSN) is a protein
from Homo sapiens identified by UniProt accession
Q13702, 412 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | 43 kDa receptor-associated protein of the synapse |
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| UniProt accession | Q13702 |
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| Gene | RAPSN |
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| Organism | Homo sapiens |
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| Length | 412 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (143)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.80
- fetal akinesia deformation sequence · score 0.75
- fetal akinesia deformation sequence 1 · score 0.66
- congenital myasthenic syndrome · score 0.54
- Postsynaptic congenital myasthenic syndromes · score 0.46
- hydrops fetalis · score 0.43
- congenital myasthenic syndrome, dominant/recessive · score 0.41
- genetic disorder · score 0.41
- arthrogryposis multiplex congenita · score 0.41
- eosinophil count · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13702-F1 | alphafold | PREDICTED | 93.18 | — |
Amino-acid sequence (412 residues)
MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV TAHSEMGRYK EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSVFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNNYGKGW SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV
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