About Activin receptor type-2B
Activin receptor type-2B (ACVR2B) is a protein
from Homo sapiens identified by UniProt accession
Q13705, 512 residues long.
MolForge cross-references it against 0 known binders and
238 disease associations.
Target properties
| Protein name | Activin receptor type-2B |
|---|
| UniProt accession | Q13705 |
|---|
| Gene | ACVR2B |
|---|
| Organism | Homo sapiens |
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| Length | 512 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (238)
Diseases linked to this target (Open Targets).
- Heterotaxia · score 0.64
- visceral heterotaxy · score 0.52
- tibia fracture · score 0.46
- Dextrocardia · score 0.38
- bone disease · score 0.37
- Heterotaxy · score 0.37
- transposition of the great arteries · score 0.37
- familial isolated congenital asplenia · score 0.37
- double outlet right ventricle · score 0.37
- neuroinflammatory disorder · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13705-F1 | alphafold | PREDICTED | 83.31 | — |
Amino-acid sequence (512 residues)
MTAPWVALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI
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