CD166 antigen (ALCAM)

About CD166 antigen

CD166 antigen (ALCAM) is a protein from Homo sapiens identified by UniProt accession Q13740, 583 residues long. MolForge cross-references it against 0 known binders and 329 disease associations.

Target properties

Protein name	CD166 antigen
UniProt accession	Q13740
Gene	ALCAM
Organism	Homo sapiens
Length	583 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (329)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.41
body height · score 0.35
cortical surface area measurement · score 0.32
body mass index · score 0.31
neuroimaging measurement · score 0.29
neurodegenerative disease · score 0.29
intraocular pressure measurement · score 0.28
self reported educational attainment · score 0.28
brain measurement · score 0.28
irritability measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13740-F1	alphafold	PREDICTED	85.94	—

Amino-acid sequence (583 residues)

MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards