About Runt-related transcription factor 3
Runt-related transcription factor 3 (RUNX3) is a protein
from Homo sapiens identified by UniProt accession
Q13761, 415 residues long.
MolForge cross-references it against 0 known binders and
656 disease associations.
Target properties
| Protein name | Runt-related transcription factor 3 |
|---|
| UniProt accession | Q13761 |
|---|
| Gene | RUNX3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 415 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (656)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.47
- eosinophil count · score 0.47
- asthma · score 0.45
- lymphocyte count · score 0.44
- Eczematoid dermatitis · score 0.43
- FEV/FVC ratio · score 0.42
- hypertension · score 0.42
- hair shape measurement · score 0.41
- allergic disease · score 0.40
- allergic rhinitis · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13761-F1 | alphafold | PREDICTED | 60.56 | — |
Amino-acid sequence (415 residues)
MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP RRHRQKLEDQ TKPFPDRFGD LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN PFSDPRQFDR SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS SGGDRSPTRM LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA LSTPGRMDEA VWRPY
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