About Nuclear receptor coactivator 4
Nuclear receptor coactivator 4 (NCOA4) is a protein
from Homo sapiens identified by UniProt accession
Q13772, 614 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Nuclear receptor coactivator 4 |
|---|
| UniProt accession | Q13772 |
|---|
| Gene | NCOA4 |
|---|
| Organism | Homo sapiens |
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| Length | 614 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (208)
Diseases linked to this target (Open Targets).
- papillary thyroid carcinoma · score 0.38
- Hashimoto's thyroiditis · score 0.37
- thyroid neoplasm · score 0.37
- Thyroid Gland Undifferentiated (Anaplastic) Carcinoma · score 0.37
- follicular thyroid carcinoma · score 0.37
- Poorly Differentiated Thyroid Gland Carcinoma · score 0.37
- Benign Thyroid Gland Neoplasm · score 0.37
- Follicular Variant Thyroid Gland Papillary Carcinoma · score 0.37
- Thyroid Gland Hyalinizing Trabecular Tumor · score 0.37
- Thyroid Gland Oncocytic Follicular Carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13772-F1 | alphafold | PREDICTED | 55.98 | — |
Amino-acid sequence (614 residues)
MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK VDKEKWLYRT PLQM
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