Phorbol-12-myristate-13-acetate-induced protein 1…

About Phorbol-12-myristate-13-acetate-induced protein 1

Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) is a protein from Homo sapiens identified by UniProt accession Q13794, 54 residues long. MolForge cross-references it against 0 known binders and 308 disease associations.

Target properties

Protein name	Phorbol-12-myristate-13-acetate-induced protein 1
UniProt accession	Q13794
Gene	PMAIP1
Organism	Homo sapiens
Length	54 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (308)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
monocyte count · score 0.41
vital capacity · score 0.40
body mass index · score 0.34
high density lipoprotein cholesterol measurement · score 0.30
chronic lymphocytic leukemia · score 0.30
head and neck squamous cell carcinoma · score 0.29
physical activity measurement · score 0.28
body fat percentage · score 0.28
type 2 diabetes mellitus · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13794-F1	alphafold	PREDICTED	81.94	—

Amino-acid sequence (54 residues)

MPGKKARKNA QPSPARAPAE LEVECATQLR RFGDKLNFRQ KLLNLISKLF CSGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)