Methylglutaconyl-CoA hydratase, mitochondrial (AUH)

About Methylglutaconyl-CoA hydratase, mitochondrial

Methylglutaconyl-CoA hydratase, mitochondrial (AUH) is a protein from Homo sapiens identified by UniProt accession Q13825, 339 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Methylglutaconyl-CoA hydratase, mitochondrial
UniProt accession	Q13825
Gene	AUH
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

3-methylglutaconic aciduria type 1 · score 0.80
eosinophil count · score 0.46
bilirubin measurement · score 0.45
BMI-adjusted waist-hip ratio · score 0.45
high density lipoprotein cholesterol measurement · score 0.42
Dystonia · score 0.42
eosinophil percentage of leukocytes · score 0.35
genetic disorder · score 0.34
apolipoprotein A 1 measurement · score 0.32
leukocyte count · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13825-F1	alphafold	PREDICTED	85.70	—

Amino-acid sequence (339 residues)

MAAAVAAAPG ALGSLHAGGA RLVAACSAWL CPGLRLPGSL AGRRAGPAIW AQGWVPAAGG PAPKRGYSSE MKTEDELRVR HLEEENRGIV VLGINRAYGK NSLSKNLIKM LSKAVDALKS DKKVRTIIIR SEVPGIFCAG ADLKERAKMS SSEVGPFVSK IRAVINDIAN LPVPTIAAID GLALGGGLEL ALACDIRVAA SSAKMGLVET KLAIIPGGGG TQRLPRAIGM SLAKELIFSA RVLDGKEAKA VGLISHVLEQ NQEGDAAYRK ALDLAREFLP QGPVAMRVAK LAINQGMEVD LVTGLAIEEA CYAQTIPTKD RLEGLLAFKE KRPPRYKGE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards