About Plakophilin-1
Plakophilin-1 (PKP1) is a protein
from Homo sapiens identified by UniProt accession
Q13835, 747 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Plakophilin-1 |
|---|
| UniProt accession | Q13835 |
|---|
| Gene | PKP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 747 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- epidermolysis bullosa simplex due to plakophilin deficiency · score 0.73
- breast adenocarcinoma · score 0.27
- panic disorder · score 0.27
- endometrial cancer · score 0.26
- ovarian cancer · score 0.25
- skin aging measurement · score 0.24
- gastric adenocarcinoma · score 0.21
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.19
- hepatocellular carcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13835-F1 | alphafold | PREDICTED | 69.00 | — |
Amino-acid sequence (747 residues)
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG YPIYNGTLKR EPDNRRFSSY SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLGSKGQKTT QNRYSFYSTC SGQKAIKKCP VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL TGLLWNLSST DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREVVDP EVFFNATGCL RKRLGMRELL ALVPQRATSS RVNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN ARNAYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS GWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI ARLLQSGNSD VVRSGASLLS NMSRHPLLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMA SQPQLAKQYF SSSMLNNIIN LCRSSASPKA AEAARLLLSD MWSSKELQGV LRQQGFDRNM LGTLAGANSL RNFTSRF
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