Myelin-associated oligodendrocyte basic protein (MOBP)

About Myelin-associated oligodendrocyte basic protein

Myelin-associated oligodendrocyte basic protein (MOBP) is a protein from Homo sapiens identified by UniProt accession Q13875, 183 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Myelin-associated oligodendrocyte basic protein
UniProt accession	Q13875
Gene	MOBP
Organism	Homo sapiens
Length	183 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

cortical thickness · score 0.38
progressive supranuclear palsy · score 0.36
neuroimaging measurement · score 0.34
appendicular lean mass · score 0.33
white matter microstructure measurement · score 0.32
amyotrophic lateral sclerosis · score 0.31
visual perception measurement · score 0.31
attention deficit hyperactivity disorder · score 0.28
sporadic amyotrophic lateral sclerosis · score 0.27
brain measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13875-F1	alphafold	PREDICTED	55.66	—

Amino-acid sequence (183 residues)

MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP PRSERQPRSP PRSERQPRSP PRSERQPRSP PRSERQPRPR PEVRPPPAKQ RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS RFW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards