Protein-tyrosine kinase 6 (PTK6)

About Protein-tyrosine kinase 6

Protein-tyrosine kinase 6 (PTK6) is a protein from Homo sapiens identified by UniProt accession Q13882, 451 residues long. MolForge cross-references it against 0 known binders and 226 disease associations.

Target properties

Protein name	Protein-tyrosine kinase 6
UniProt accession	Q13882
Gene	PTK6
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (226)

Diseases linked to this target (Open Targets).

medullary thyroid gland carcinoma · score 0.53
thyroid cancer · score 0.47
non-small cell lung carcinoma · score 0.46
thyroid carcinoma · score 0.46
neoplasm · score 0.42
cutaneous melanoma · score 0.41
thyroid neoplasm · score 0.39
colorectal adenocarcinoma · score 0.38
gastric carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13882-F1	alphafold	PREDICTED	88.79	—

Amino-acid sequence (451 residues)

MVSRDQAHLG PKYVGLWDFK SRTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG YVPHNYLAER ETVESEPWFF GCISRSEAVR RLQAEGNATG AFLIRVSEKP SADYVLSVRD TQAVRHYKIW RRAGGRLHLN EAVSFLSLPE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ MLQSEIQAMK KLRHKHILAL YAVVSVGDPV YIITELMAKG SLLELLRDSD EKVLPVSELL DIAWQVAEGM CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDHNIP YKWTAPEALS RGHYSTKSDV WSFGILLHEM FSRGQVPYPG MSNHEAFLRV DAGYRMPCPL ECPPSVHKLM LTCWCRDPEQ RPCFKALRER LSSFTSYENP T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards