Krueppel-like factor 5 (KLF5)

About Krueppel-like factor 5

Krueppel-like factor 5 (KLF5) is a protein from Homo sapiens identified by UniProt accession Q13887, 457 residues long. MolForge cross-references it against 0 known binders and 339 disease associations.

Target properties

Protein name	Krueppel-like factor 5
UniProt accession	Q13887
Gene	KLF5
Organism	Homo sapiens
Length	457 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (339)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
monocyte count · score 0.38
cervical squamous cell carcinoma · score 0.37
colorectal cancer · score 0.36
squamous cell lung carcinoma · score 0.34
Eczematoid dermatitis · score 0.34
urinary bladder cancer · score 0.34
dilated cardiomyopathy 1FF · score 0.33
neutrophil count · score 0.33
colorectal adenoma · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13887-F1	alphafold	PREDICTED	46.88	—

Amino-acid sequence (457 residues)

MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards