General transcription factor IIH subunit 2 (GTF2H2)

About General transcription factor IIH subunit 2

General transcription factor IIH subunit 2 (GTF2H2) is a protein from Homo sapiens identified by UniProt accession Q13888, 395 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	General transcription factor IIH subunit 2
UniProt accession	Q13888
Gene	GTF2H2
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
neurodegenerative disease · score 0.54
total blood protein measurement · score 0.26
squamous cell lung carcinoma · score 0.18
mean corpuscular volume · score 0.17
clear cell renal carcinoma · score 0.17
platelet component distribution width · score 0.14
urinary bladder cancer · score 0.12
blood protein measurement · score 0.07
severe malarial anemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13888-F1	alphafold	PREDICTED	84.33	—

Amino-acid sequence (395 residues)

MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH GEPSLYNSLS IAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHVSPPP ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG ELKDQHVYVC AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards