About General transcription factor IIH subunit 3
General transcription factor IIH subunit 3 (GTF2H3) is a protein
from Homo sapiens identified by UniProt accession
Q13889, 308 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | General transcription factor IIH subunit 3 |
|---|
| UniProt accession | Q13889 |
|---|
| Gene | GTF2H3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 308 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.24
- head and neck squamous cell carcinoma · score 0.18
- lung adenocarcinoma · score 0.18
- squamous cell lung carcinoma · score 0.18
- neurodegenerative disease · score 0.18
- CACH syndrome · score 0.16
- urinary bladder cancer · score 0.12
- lymphocyte count · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13889-F1 | alphafold | PREDICTED | 80.51 | — |
Amino-acid sequence (308 residues)
MVSDEDELNL LVIVVDANPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI ASHIQESRFL YPGKNGRLGD FFGDPGNPPE FNPSGSKDGK YELLTSANEV IVEEIKDLMT KSDIKGQHTE TLLAGSLAKA LCYIHRMNKE VKDNQEMKSR ILVIKAAEDS ALQYMNFMNV IFAAQKQNIL IDACVLDSDS GLLQQACDIT GGLYLKVPQM PSLLQYLLWV FLPDQDQRSQ LILPPPVHVD YRAACFCHRN LIEIGYVCSV CLSIFCNFSP ICTTCETAFK ISLPPVLKAK KKKLKVSA
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