About High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A) is a protein
from Homo sapiens identified by UniProt accession
Q13946, 482 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A |
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| UniProt accession | Q13946 |
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| Gene | PDE7A |
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| Organism | Homo sapiens |
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| Length | 482 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (186)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.55
- stroke · score 0.55
- Hepatitis, Alcoholic · score 0.48
- diabetic nephropathy · score 0.47
- chronic kidney disease · score 0.47
- Myocardial Ischemia · score 0.47
- urethritis · score 0.46
- diabetes mellitus · score 0.46
- urinary tract infection · score 0.46
- prostatitis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13946-F1 | alphafold | PREDICTED | 78.40 | — |
Amino-acid sequence (482 residues)
MEVCYQLPVL PLDRPVPQHV LSRRGAISFS SSSALFGCPN PRQLSQRRGA ISYDSSDQTA LYIRMLGDVR VRSRAGFESE RRGSHPYIDF RIFHSQSEIE VSVSARNIRR LLSFQRYLRS SRFFRGTAVS NSLNILDDDY NGQAKCMLEK VGNWNFDIFL FDRLTNGNSL VSLTFHLFSL HGLIEYFHLD MMKLRRFLVM IQEDYHSQNP YHNAVHAADV TQAMHCYLKE PKLANSVTPW DILLSLIAAA THDLDHPGVN QPFLIKTNHY LATLYKNTSV LENHHWRSAV GLLRESGLFS HLPLESRQQM ETQIGALILA TDISRQNEYL SLFRSHLDRG DLCLEDTRHR HLVLQMALKC ADICNPCRTW ELSKQWSEKV TEEFFHQGDI EKKYHLGVSP LCDRHTESIA NIQIGFMTYL VEPLFTEWAR FSNTRLSQTM LGHVGLNKAS WKGLQREQSS SEDTDAAFEL NSQLLPQENR LS
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