About Runt-related transcription factor 2
Runt-related transcription factor 2 (RUNX2) is a protein
from Homo sapiens identified by UniProt accession
Q13950, 521 residues long.
MolForge cross-references it against 0 known binders and
987 disease associations.
Target properties
| Protein name | Runt-related transcription factor 2 |
|---|
| UniProt accession | Q13950 |
|---|
| Gene | RUNX2 |
|---|
| Organism | Homo sapiens |
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| Length | 521 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (987)
Diseases linked to this target (Open Targets).
- cleidocranial dysplasia 1 · score 0.84
- metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome · score 0.69
- Metaphyseal dysplasia - maxillary hypoplasia - brachydacty · score 0.66
- neurodegenerative disease · score 0.48
- brain volume measurement · score 0.47
- genetic disorder · score 0.46
- neuroimaging measurement · score 0.46
- eosinophil count · score 0.45
- refractive error measurement · score 0.45
- cortical thickness · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13950-F1 | alphafold | PREDICTED | 58.62 | — |
Amino-acid sequence (521 residues)
MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ QQQQQQQQQQ QEAAAAAAAA AAAAAAAAAV PRLRPPHDNR TMVEIIADHP AELVRTDSPN FLCSVLPSHW RCNKTLPVAF KVVALGEVPD GTVVTVMAGN DENYSAELRN ASAVMKNQVA RFNDLRFVGR SGRGKSFTLT ITVFTNPPQV ATYHRAIKVT VDGPREPRRH RQKLDDSKPS LFSDRLSDLG RIPHPSMRVG VPPQNPRPSL NSAPSPFNPQ GQSQITDPRQ AQSSPPWSYD QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS DDDTATSDFC LWPSTLSKKS QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY TPPVTSGMSL GMSATTHYHT YLPPPYPGSS QSQSGPFQTS STPYLYYGTS SGSYQFPMVP GGDRSPSRML PPCTTTSNGS TLLNPNLPNQ NDGVDADGSH SSSPTVLNSS GRMDESVWRP Y
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