About Core-binding factor subunit beta
Core-binding factor subunit beta (CBFB) is a protein
from Homo sapiens identified by UniProt accession
Q13951, 182 residues long.
MolForge cross-references it against 0 known binders and
290 disease associations.
Target properties
| Protein name | Core-binding factor subunit beta |
|---|
| UniProt accession | Q13951 |
|---|
| Gene | CBFB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 182 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (290)
Diseases linked to this target (Open Targets).
- cleidocranial dysplasia 1 · score 0.54
- breast adenocarcinoma · score 0.52
- breast ductal adenocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
- esophageal adenocarcinoma · score 0.37
- breast carcinoma · score 0.37
- lobular breast carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13951-F1 | alphafold | PREDICTED | 85.83 | — |
Amino-acid sequence (182 residues)
MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP
Explore Core-binding factor subunit beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets