Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic…

About Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6H) is a protein from Homo sapiens identified by UniProt accession Q13956, 83 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt accession	Q13956
Gene	PDE6H
Organism	Homo sapiens
Length	83 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

achromatopsia · score 0.64
coronary artery disease · score 0.55
stroke · score 0.55
Hepatitis, Alcoholic · score 0.48
diabetic nephropathy · score 0.47
chronic kidney disease · score 0.47
Myocardial Ischemia · score 0.47
diabetes mellitus · score 0.46
non-alcoholic steatohepatitis · score 0.45
cardiovascular disease · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13956-F1	alphafold	PREDICTED	66.99	—

Amino-acid sequence (83 residues)

MSDNTTLPAP ASNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI TVICPWEAFS HLELHELAQF GII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6H)