About cGMP-dependent protein kinase 1
cGMP-dependent protein kinase 1 (PRKG1) is a protein
from Homo sapiens identified by UniProt accession
Q13976, 671 residues long.
MolForge cross-references it against 0 known binders and
589 disease associations.
Target properties
| Protein name | cGMP-dependent protein kinase 1 |
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| UniProt accession | Q13976 |
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| Gene | PRKG1 |
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| Organism | Homo sapiens |
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| Length | 671 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (589)
Diseases linked to this target (Open Targets).
- familial thoracic aortic aneurysm and aortic dissection · score 0.67
- body height · score 0.50
- lean body mass · score 0.46
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.43
- appendicular lean mass · score 0.42
- calcium measurement · score 0.41
- Rare genetic vascular disease · score 0.37
- fat body mass · score 0.37
- vital capacity · score 0.34
- interferon alpha measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13976-F1 | alphafold | PREDICTED | 86.67 | — |
Amino-acid sequence (671 residues)
MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP STHIGPRTTR AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD NDFMKNLELS QIQEIVDCMY PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV TKEGVKLCTM GPGKVFGELA ILYNCTRTAT VKTLVNVKLW AIDRQCFQTI MMRTGLIKHT EYMEFLKSVP TFQSLPEEIL SKLADVLEET HYENGEYIIR QGARGDTFFI ISKGTVNVTR EDSPSEDPVF LRTLGKGDWF GEKALQGEDV RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA FFANLKLSDF NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD SFPEDNDEPP PDDNSGWDID F
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