About Voltage-gated potassium channel KCNC3
Voltage-gated potassium channel KCNC3 (KCNC3) is a protein
from Homo sapiens identified by UniProt accession
Q14003, 757 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Voltage-gated potassium channel KCNC3 |
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| UniProt accession | Q14003 |
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| Gene | KCNC3 |
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| Organism | Homo sapiens |
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| Length | 757 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 13 · score 0.82
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- genetic disorder · score 0.41
- primary progressive multiple sclerosis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
- transverse myelitis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14003-F1 | alphafold | PREDICTED | 64.10 | — |
Amino-acid sequence (757 residues)
MLSSVCVSSF RGRQGASKQQ PAPPPQPPES PPPPPLPPQQ QQPAQPGPAA SPAGPPAPRG PGDRRAEPCP GLPAAAMGRH GGGGGDSGKI VINVGGVRHE TYRSTLRTLP GTRLAGLTEP EAAARFDYDP GADEFFFDRH PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LGFWGIDETD VEACCWMTYR QHRDAEEALD SFEAPDPAGA ANAANAAGAH DGGLDDEAGA GGGGLDGAGG ELKRLCFQDA GGGAGGPPGG AGGAGGTWWR RWQPRVWALF EDPYSSRAAR YVAFASLFFI LISITTFCLE THEGFIHISN KTVTQASPIP GAPPENITNV EVETEPFLTY VEGVCVVWFT FEFLMRITFC PDKVEFLKSS LNIIDCVAIL PFYLEVGLSG LSSKAAKDVL GFLRVVRFVR ILRIFKLTRH FVGLRVLGHT LRASTNEFLL LIIFLALGVL IFATMIYYAE RIGADPDDIL GSNHTYFKNI PIGFWWAVVT MTTLGYGDMY PKTWSGMLVG ALCALAGVLT IAMPVPVIVN NFGMYYSLAM AKQKLPKKKN KHIPRPPQPG SPNYCKPDPP PPPPPHPHHG SGGISPPPPI TPPSMGVTVA GAYPAGPHTH PGLLRGGAGG LGIMGLPPLP APGEPCPLAQ EEVIEINRAD PRPNGDPAAA ALAHEDCPAI DQPAMSPEDK SPITPGSRGR YSRDRACFLL TDYAPSPDGS IRKATGAPPL PPQDWRKPGP PSFLPDLNAN AAAWISP
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