Cold-inducible RNA-binding protein (CIRBP)

About Cold-inducible RNA-binding protein

Cold-inducible RNA-binding protein (CIRBP) is a protein from Homo sapiens identified by UniProt accession Q14011, 172 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Cold-inducible RNA-binding protein
UniProt accession	Q14011
Gene	CIRBP
Organism	Homo sapiens
Length	172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.17
mean corpuscular hemoglobin · score 0.12
neoplasm · score 0.11
alkaline phosphatase measurement · score 0.09
cancer · score 0.09
non-small cell lung carcinoma · score 0.09
Sepsis · score 0.09
mean corpuscular hemoglobin concentration · score 0.08
infection · score 0.08
infect · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14011-F1	alphafold	PREDICTED	61.38	—

Amino-acid sequence (172 residues)

MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards