About Calcium/calmodulin-dependent protein kinase type 1
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) is a protein
from Homo sapiens identified by UniProt accession
Q14012, 370 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase type 1 |
|---|
| UniProt accession | Q14012 |
|---|
| Gene | CAMK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 370 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- pachyonychia congenita · score 0.07
- essential tremor · score 0.04
- Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.04
- spinocerebellar ataxia type 20 · score 0.04
- episodic ataxia type 1 · score 0.04
- Young adult-onset Parkinsonism · score 0.04
- isolated dystonia · score 0.04
- spinocerebellar ataxia type 15/16 · score 0.04
- miotic rate · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14012-F1 | alphafold | PREDICTED | 78.36 | — |
Amino-acid sequence (370 residues)
MLGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKEALEGKE GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP VAGGPAAGCC CRDCCVEPGT ELSPTLPHQL
Explore Calcium/calmodulin-dependent protein kinase type 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets