Coactosin-like protein (COTL1)

About Coactosin-like protein

Coactosin-like protein (COTL1) is a protein from Homo sapiens identified by UniProt accession Q14019, 142 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	Coactosin-like protein
UniProt accession	Q14019
Gene	COTL1
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

diffuse plaque measurement · score 0.30
lymphocyte count · score 0.15
FEV/FVC ratio · score 0.14
monocyte count · score 0.13
HbA1c measurement · score 0.13
mean platelet volume · score 0.13
neoplasm · score 0.09
leukocyte count · score 0.09
cancer · score 0.08
glioblastoma multiforme · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14019-F1	alphafold	PREDICTED	90.37	—

Amino-acid sequence (142 residues)

MATKIDKEAC RAAYNLVRDD GSAVIWVTFK YDGSTIVPGE QGAEYQHFIQ QCTDDVRLFA FVRFTTGDAM SKRSKFALIT WIGENVSGLQ RAKTGTDKTL VKEVVQNFAK EFVISDRKEL EEDFIKSELK KAGGANYDAQ TE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards