Bile acid-CoA:amino acid N-acyltransferase (BAAT)

About Bile acid-CoA:amino acid N-acyltransferase

Bile acid-CoA:amino acid N-acyltransferase (BAAT) is a protein from Homo sapiens identified by UniProt accession Q14032, 418 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Bile acid-CoA:amino acid N-acyltransferase
UniProt accession	Q14032
Gene	BAAT
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

hypercholanemia, familial · score 0.67
bile acid conjugation defect 1 · score 0.65
Cholestasis · score 0.46
cholestasis · score 0.46
C-reactive protein measurement · score 0.27
hypercholanemia, familial 1 · score 0.19
cutaneous melanoma · score 0.15
protein measurement · score 0.06
dehydrated hereditary stomatocytosis · score 0.04
Familial hemophagocytic lymphohistiocytosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14032-F1	alphafold	PREDICTED	95.17	—

Amino-acid sequence (418 residues)

MIQLTATPVS ALVDEPVHIR ATGLIPFQMV SFQASLEDEN GDMFYSQAHY RANEFGEVDL NHASSLGGDY MGVHPMGLFW SLKPEKLLTR LLKRDVMNRP FQVQVKLYDL ELIVNNKVAS APKASLTLER WYVAPGVTRI KVREGRLRGA LFLPPGEGLF PGVIDLFGGL GGLLEFRASL LASRGFASLA LAYHNYEDLP RKPEVTDLEY FEEAANFLLR HPKVFGSGVG VVSVCQGVQI GLSMAIYLKQ VTATVLINGT NFPFGIPQVY HGQIHQPLPH SAQLISTNAL GLLELYRTFE TTQVGASQYL FPIEEAQGQF LFIVGEGDKT INSKAHAEQA IGQLKRHGKN NWTLLSYPGA GHLIEPPYSP LCCASTTHDL RLHWGGEVIP HAAAQEHAWK EIQRFLRKHL IPDVTSQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards