About Collagen alpha-3(IX) chain
Collagen alpha-3(IX) chain (COL9A3) is a protein
from Homo sapiens identified by UniProt accession
Q14050, 684 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Collagen alpha-3(IX) chain |
|---|
| UniProt accession | Q14050 |
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| Gene | COL9A3 |
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| Organism | Homo sapiens |
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| Length | 684 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (98)
Diseases linked to this target (Open Targets).
- Stickler syndrome · score 0.71
- multiple epiphyseal dysplasia due to collagen 9 anomaly · score 0.61
- lumbar disc degeneration · score 0.46
- Stickler syndrom, recessive · score 0.43
- genetic disorder · score 0.42
- BMI-adjusted waist circumference · score 0.38
- connective tissue disease · score 0.36
- retinal detachment · score 0.35
- Lattice retinal degeneration · score 0.32
- body height · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14050-F1 | alphafold | PREDICTED | 54.78 | — |
Amino-acid sequence (684 residues)
MAGPRACAPL LLLLLLGELL AAAGAQRVGL PGPPGPPGPP GKPGQDGIDG EAGPPGLPGP PGPKGAPGKP GKPGEAGLPG LPGVDGLTGR DGPPGPKGAP GERGSLGPPG PPGLGGKGLP GPPGEAGVSG PPGGIGLRGP PGPSGLPGLP GPPGPPGPPG HPGVLPEGAT DLQCPSICPP GPPGPPGMPG FKGPTGYKGE QGEVGKDGEK GDPGPPGPAG LPGSVGLQGP RGLRGLPGPL GPPGDRGPIG FRGPPGIPGA PGKAGDRGER GPEGFRGPKG DLGRPGPKGT PGVAGPSGEP GMPGKDGQNG VPGLDGQKGE AGRNGAPGEK GPNGLPGLPG RAGSKGEKGE RGRAGELGEA GPSGEPGVPG DAGMPGERGE AGHRGSAGAL GPQGPPGAPG VRGFQGQKGS MGDPGLPGPQ GLRGDVGDRG PGGAAGPKGD QGIAGSDGLP GDKGELGPSG LVGPKGESGS RGELGPKGTQ GPNGTSGVQG VPGPPGPLGL QGVPGVPGIT GKPGVPGKEA SEQRIRELCG GMISEQIAQL AAHLRKPLAP GSIGRPGPAG PPGPPGPPGS IGHPGARGPP GYRGPTGELG DPGPRGNQGD RGDKGAAGAG LDGPEGDQGP QGPQGVPGTS KDGQDGAPGE PGPPGDPGLP GAIGAQGTPG ICDTSACQGA VLGGVGEKSG SRSS
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