About Collagen alpha-2(IX) chain
Collagen alpha-2(IX) chain (COL9A2) is a protein
from Homo sapiens identified by UniProt accession
Q14055, 689 residues long.
MolForge cross-references it against 0 known binders and
197 disease associations.
Target properties
| Protein name | Collagen alpha-2(IX) chain |
|---|
| UniProt accession | Q14055 |
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| Gene | COL9A2 |
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| Organism | Homo sapiens |
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| Length | 689 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (197)
Diseases linked to this target (Open Targets).
- multiple epiphyseal dysplasia due to collagen 9 anomaly · score 0.69
- Stickler syndrome · score 0.49
- lumbar disc degeneration · score 0.40
- Stickler syndrom, recessive · score 0.37
- body height · score 0.36
- breast adenocarcinoma · score 0.27
- Intellectual disability · score 0.27
- thyroid gland adenocarcinoma · score 0.25
- BMI-adjusted hip circumference · score 0.22
- BMI-adjusted waist circumference · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14055-F1 | alphafold | PREDICTED | 54.54 | — |
Amino-acid sequence (689 residues)
MAAATASPRS LLVLLQVVVL ALAQIRGPPG ERGPPGPPGP PGVPGSDGID GDNGPPGKAG PPGPKGEPGK AGPDGPDGKP GIDGLTGAKG EPGPMGIPGV KGQPGLPGPP GLPGPGFAGP PGPPGPVGLP GEIGIRGPKG DPGPDGPSGP PGPPGKPGRP GTIQGLEGSA DFLCPTNCPP GMKGPPGLQG VKGHAGKRGI LGDPGHQGKP GPKGDVGASG EQGIPGPPGP QGIRGYPGMA GPKGETGPHG YKGMVGAIGA TGPPGEEGPR GPPGRAGEKG DEGSPGIRGP QGITGPKGAT GPPGINGKDG TPGTPGMKGS AGQAGQPGSP GHQGLAGVPG QPGTKGGPGD QGEPGPQGLP GFSGPPGKEG EPGPRGEIGP QGIMGQKGDQ GERGPVGQPG PQGRQGPKGE QGPPGIPGPQ GLPGVKGDKG SPGKTGPRGK VGDPGVAGLP GEKGEKGESG EPGPKGQQGV RGEPGYPGPS GDAGAPGVQG YPGPPGPRGL AGNRGVPGQP GRQGVEGRDA TDQHIVDVAL KMLQEQLAEV AVSAKREALG AVGMMGPPGP PGPPGYPGKQ GPHGHPGPRG VPGIVGAVGQ IGNTGPKGKR GEKGDPGEVG RGHPGMPGPP GIPGLPGRPG QAINGKDGDR GSPGAPGEAG RPGLPGPVGL PGFCEPAACL GASAYASARL TEPGSIKGP
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