About Ras-related protein Rab-33A
Ras-related protein Rab-33A (RAB33A) is a protein
from Homo sapiens identified by UniProt accession
Q14088, 237 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Ras-related protein Rab-33A |
|---|
| UniProt accession | Q14088 |
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| Gene | RAB33A |
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| Organism | Homo sapiens |
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| Length | 237 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- Hereditary persistence of alpha-fetoprotein · score 0.04
- congenital lethal erythroderma · score 0.03
- Congenital deficiency in alpha-fetoprotein · score 0.03
- ependymoma · score 0.02
- Acute hepatic failure · score 0.01
- melanoma · score 0.01
- Alzheimer disease · score 0.01
- tuberculosis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14088-F1 | alphafold | PREDICTED | 81.34 | — |
Amino-acid sequence (237 residues)
MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
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