Cyclin-I (CCNI)

About Cyclin-I

Cyclin-I (CCNI) is a protein from Homo sapiens identified by UniProt accession Q14094, 377 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Cyclin-I
UniProt accession	Q14094
Gene	CCNI
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.21
monocyte count · score 0.16
nephrotic syndrome · score 0.09
familial idiopathic steroid-resistant nephrotic syndrome · score 0.09
focal segmental glomerulosclerosis · score 0.08
familial juvenile hyperuricemic nephropathy type 1 · score 0.07
congenital nephrotic syndrome, Finnish type · score 0.07
nail-patella-like renal disease · score 0.07
nephronophthisis · score 0.07
Dent disease · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14094-F1	alphafold	PREDICTED	72.43	—

Amino-acid sequence (377 residues)

MKFPGPLENQ RLSFLLEKAI TREAQMWKVN VRKMPSNQNV SPSQRDEVIQ WLAKLKYQFN LYPETFALAS SLLDRFLATV KAHPKYLSCI AISCFFLAAK TVEEDERIPV LKVLARDSFC GCSSSEILRM ERIILDKLNW DLHTATPLDF LHIFHAIAVS TRPQLLFSLP KLSPSQHLAV LTKQLLHCMA CNQLLQFRGS MLALAMVSLE MEKLIPDWLS LTIELLQKAQ MDSSQLIHCR ELVAHHLSTL QSSLPLNSVY VYRPLKHTLV TCDKGVFRLH PSSVPGPDFS KDNSKPEVPV RGTAAFYHHL PAASGCKQTS TKRKVEEMEV DDFYDGIKRL YNEDNVSENV GSVCGTDLSR QEGHASPCPP LQPVSVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards