Lysosome membrane protein 2 (SCARB2)

About Lysosome membrane protein 2

Lysosome membrane protein 2 (SCARB2) is a protein from Homo sapiens identified by UniProt accession Q14108, 478 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Lysosome membrane protein 2
UniProt accession	Q14108
Gene	SCARB2
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

action myoclonus-renal failure syndrome · score 0.78
Action myoclonus - renal failure syndrome · score 0.69
Progressive myoclonic epilepsy · score 0.55
genetic disorder · score 0.47
childhood epilepsy with centrotemporal spikes · score 0.42
Rolandic epilepsy · score 0.42
progressive myoclonus epilepsy · score 0.38
Unverricht-Lundborg disease · score 0.37
Gaucher disease type 1 · score 0.37
Unverricht-Lundborg syndrome · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14108-F1	alphafold	PREDICTED	92.75	—

Amino-acid sequence (478 residues)

MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards